PhD with individual research topic

Hello,
after my diploma in Systems Biology of Bacteria, I've still reflected on a continuation of research in this most exciting field in Life Science.
Even during my diploma project, I observed the simpleness of E.coli cultivation on 20 degree. That brought me to the idea of modelling the cold stress response in E.coli, due to the less experimental effort comparing transcription at 20° and 37°. Besides there're many new insights in transcriptional regulation modelling and cold shock response research in the last 15 years and almost all experiments
in this project can be done at low cost by usage of standard lab kits.
Who can give me some hints in writing a research proposal for an application. Or who knows researchers in this field, who are interessted in a cooperation.

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