Genome Calligrapher

The Genome Calligrapher is a web server based software tool developed by the ChristenLab at ETH Zurich that allows the synthetic biologist to refactor and streamline DNA sequences from single genes up to whole microbial genomes for de novo DNA synthesis. By applying a neutral recoding algorithm the Genome Calligrapher removes unwanted and obstructive DNA sequence known to impede DNA synthesis. In a user-friendly process you can upload any GenBank file and optimise its GC content, replace unfavored synthesis patterns such as homopolymeric streches, di- and trinucleotide repeats, hairpins and direct repeats as well as user specified disallowed sequence patterns that might interfere with DNA synthesis or higher order assembly.

Extracted from genome Calligrapher website.

Developers / Authors
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Institute of Molecular Systems Biology
Who uses this tool/resource?
Institute of Molecular Systems Biology
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